GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs17761864 | 1 | rs10445300 | chr17:2114587 | SRR | chr17:2207248-2228553:+ | -0.53 | -5.47 | 3.67E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | CCDC163P | chr1:45960581-45965646:- | -0.86 | -14.78 | 2.3E-26 | Homocysteine levels |
| THYM | cis | rs1577917 | 1 | rs10455158 | chr6:86672825 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2294008 | 1 | rs1045531 | chr8:143763547 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs1577917 | 1 | rs10455449 | chr6:86592226 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -7.35 | 6.78E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs10455455 | chr6:86670214 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -7.24 | 1.15E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs10455456 | chr6:86670322 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2294008 | 1 | rs1045547 | chr8:143763757 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2294008 | 1 | rs1045605 | chr8:143764101 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | CENPQ | chr6:49431096-49460820:+ | -0.23 | -4.18 | 6.44E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | MUT | chr6:49398994-49431031:- | 0.28 | 4.34 | 3.5E-5 | Folate pathway vitamin levels |
| THYM | cis | rs10461617 | 1 | rs10461617 | chr5:56104308 | C5orf35 | chr5:56205103-56213010:+ | 0.73 | 8.85 | 4.68E-14 | Type 2 diabetes |
| THYM | cis | rs9876781 | 1 | rs10470686 | chr3:48449956 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.43 | 2.49E-5 | Longevity |
| THYM | cis | rs11799420 | 1 | rs10489249 | chr1:171714521 | VAMP4 | chr1:171669298-171711214:- | 0.32 | 4.18 | 6.49E-5 | Hippocampal atrophy |